SCHEMBL28290036

SCHEMBL28290036

CN(C(=O)C#Cc1ccccc1)c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.60
UTS2R Q9UKP6 1/20 0.47
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
LMNA P02545 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
ALDH1A1 P00352 3/20 0.42
GPBAR1 Q8TDU6 4/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
POLB P06746 1/20 0.41
VCP P55072 1/20 0.41
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
DRD4 P21917 1/20 0.40
DRD2 P14416 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR2B P41595 1/20 0.39
SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25918159 0.89 NPSR1 (0.70) NPSR1MEN1KMT2ANPC1RAB9A
SCHEMBL28291463 0.84 NPSR1 (0.60) NPSR1GPBAR1NPC1RAB9APOLB
SCHEMBL28290037 0.82 NPSR1 (0.57) NPSR1MEN1KMT2ALMNAL3MBTL1
SCHEMBL28291465 0.80 NPSR1 (0.54) NPSR1LMNAALDH1A1NPC1RAB9A
SCHEMBL22079525 0.79 NPSR1 (0.57) NPSR1UTS2RMEN1KMT2ANPC1
SCHEMBL3866501 0.79 CHRM1 (0.41) NPSR1UTS2RALDH1A1GPBAR1RAB9A
SCHEMBL11636289 0.76 NPSR1 (1.00) NPSR1UTS2RMEN1KMT2AALDH1A1
SCHEMBL3856302 0.75 MCHR1 (0.51) KDM4ESIGMAR1CYP1A2CYP3A4CYP2C19
SCHEMBL3861766 0.73 MCHR1 (0.64) ALDH1A1KDM4EDRD4HTR2ACYP2D6
SCHEMBL692996 0.72 ALDH1A1 (0.48) MEN1KMT2ALMNAL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107141248-B A kind of method of visible light catalytic synthesis three ketene compound of 3- sulfuryl loop coil 曲阜师范大学 2019-04-30 CN disclosed