SCHEMBL28291465

SCHEMBL28291465

CCOc1ccc(N(C)C(=O)C#Cc2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.54
POLB P06746 2/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
MAPK1 P28482 1/20 0.48
FFAR1 O14842 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
LTA4H P09960 1/20 0.42
ACACB O00763 5/20 0.42
MLYCD O95822 2/20 0.42
TSHR P16473 1/20 0.42
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28290037 0.86 NPSR1 (0.57) NPSR1POLBNPC1RAB9AALDH1A1
SCHEMBL3859101 0.85 MCHR1 (0.53) NPSR1ALDH1A1MAPTLTA4HACACB
SCHEMBL25918159 0.83 NPSR1 (0.70) NPSR1POLBNPC1RAB9AACACB
SCHEMBL28291463 0.80 NPSR1 (0.60) NPSR1POLBNPC1RAB9AMAPT
SCHEMBL28290036 0.80 NPSR1 (0.60) NPSR1POLBNPC1RAB9AALDH1A1
SCHEMBL6246382 0.79 FFAR1 (0.56) NPSR1POLBNPC1RAB9AMAPT
SCHEMBL22079525 0.75 NPSR1 (0.57) NPSR1POLBNPC1RAB9AMAPT
SCHEMBL3832407 0.74 ALDH1A1 (0.77) POLBNPC1RAB9AALDH1A1LMNA
SCHEMBL27914449 0.74 FFAR1 (0.56) NPC1ALDH1A1FFAR1ACACB
SCHEMBL3861889 0.74 MCHR1 (0.64) ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107337663-B A kind of preparation method of thio three ketene compound of loop coil of visible light-inducing 3- 曲阜师范大学 2019-09-17 CN disclosed
CN-107141248-B A kind of method of visible light catalytic synthesis three ketene compound of 3- sulfuryl loop coil 曲阜师范大学 2019-04-30 CN disclosed