Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289034 | 0.92 | MAPK1 (0.47) | MAPK1DRD2DRD4ALDH1A1PTGER4 | |
| SCHEMBL21551742 | 0.79 | MAPK1 (0.47) | MAPK1DRD2DRD4ALDH1A1OPRM1 | |
| SCHEMBL19057548 | 0.79 | ALDH1A1 (0.61) | DRD2ALDH1A1PTGER4KDM4EMAPT | |
| SCHEMBL28290450 | 0.75 | ALDH1A1 (0.49) | ALDH1A1PTGER4DRD3KDM4EMAPT | |
| SCHEMBL28703960 | 0.75 | TRIM24 (0.55) | DRD2ALDH1A1DRD3KDM4EMAPT | |
| SCHEMBL28694827 | 0.72 | ALDH1A1 (0.55) | DRD2DRD4ALDH1A1KDM4ETRIM24 | |
| SCHEMBL28690294 | 0.71 | ALDH1A1 (0.58) | DRD2ALDH1A1DRD3KDM4ETRIM24 | |
| SCHEMBL28290449 | 0.71 | ALDH1A1 (0.47) | ALDH1A1DRD3KDM4EMAPTTRIM24 | |
| SCHEMBL23346305 | 0.71 | MAPT (0.39) | MAPK1ALDH1A1MAPTTSHR | |
| SCHEMBL28699857 | 0.70 | ALDH1A1 (0.56) | DRD2DRD4ALDH1A1DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |