Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28290449 | 0.93 | ALDH1A1 (0.47) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL19057548 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL28290432 | 0.75 | MAPK1 (0.49) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL13849418 | 0.75 | DPP4 (0.40) | CTSCMAPTDRD3LRRK2ADORA2A | |
| SCHEMBL22642860 | 0.75 | CTSC (0.47) | CTSCMAPTDRD3LRRK2MAP3K12 | |
| SCHEMBL13849417 | 0.75 | DPP4 (0.40) | CTSCMAPTDRD3LRRK2ADORA2A | |
| SCHEMBL13849432 | 0.74 | MAP3K12 (0.40) | ALDH1A1CTSCDRD3LRRK2ADORA2A | |
| SCHEMBL28703960 | 0.74 | TRIM24 (0.55) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL28690294 | 0.73 | ALDH1A1 (0.58) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL28690267 | 0.73 | ALDH1A1 (0.50) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |