Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28290431 | 0.88 | KDM4E (0.47) | KDM4EPOLBHRH3CHRNB2CHRNA4 | |
| Pyridine SCHEMBL28167226 | 0.85 | TP53 (0.44) | KDM4EPOLBTP53MDM2 | |
| SCHEMBL104699 | 0.82 | SIGMAR1 (0.51) | — | |
| SCHEMBL104187 | 0.82 | SIGMAR1 (0.51) | — | |
| SCHEMBL104186 | 0.82 | SIGMAR1 (0.51) | — | |
| SCHEMBL27930152 | 0.81 | CHRNB2 (0.46) | KDM4EPOLBCHRNB2CHRNA4TP53 | |
| Hydrochloric Acid SCHEMBL27966160 | 0.81 | SIGMAR1 (0.50) | — | |
| SCHEMBL8290762 | 0.81 | KDM4E (0.69) | KDM4EPOLBHRH3CHRNB2CHRNA4 | |
| SCHEMBL18291385 | 0.81 | ALDH1A1 (0.45) | KDM4EPOLBHRH3CHRNB2CHRNA4 | |
| SCHEMBL4629587 | 0.80 | CHRNB2 (0.44) | KDM4EPOLBCHRNB2CHRNA4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |