Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826472 | 0.83 | GRM5 (0.41) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826446 | 0.83 | GRM5 (0.46) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL2833178 | 0.83 | GRM5 (0.48) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL2830053 | 0.80 | GRM5 (0.41) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL2830980 | 0.79 | GRM5 (0.48) | GRM5SORT1MAPTMAPK14MEN1 | |
| SCHEMBL2828392 | 0.79 | GRM5 (0.52) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL2826716 | 0.78 | GRM5 (0.50) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL2826248 | 0.77 | SMARCA2 (0.56) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL2830138 | 0.77 | GRM5 (0.49) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2828828 | 0.77 | GRM5 (0.46) | GRM5SORT1SMARCA2SMARCA4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |