Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828392 | 0.84 | GRM5 (0.52) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2830980 | 0.83 | GRM5 (0.48) | GRM5SORT1SYK | |
| SCHEMBL2829105 | 0.83 | GRM5 (0.42) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2826714 | 0.83 | GRM5 (0.70) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2833093 | 0.82 | GRM5 (0.69) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2826716 | 0.82 | GRM5 (0.50) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2829934 | 0.82 | GRM5 (0.52) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2826248 | 0.81 | SMARCA2 (0.56) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2831334 | 0.81 | GRM5 (0.54) | GRM5PORCNSORT1SMARCA2SMARCA4 | |
| SCHEMBL2833088 | 0.81 | GRM5 (0.56) | GRM5PORCNSORT1SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |