Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.43 |
| ▸ | GLRB | P48167 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27556882 | 0.85 | GABRA1 (0.54) | ALDH1A1TDP1TSHRCA2ATM | |
| Propionic Acid SCHEMBL28419513 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL28374037 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL1807676 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL5167215 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2ATM | |
| Methyl Alcohol SCHEMBL28457865 | 0.85 | ALDH1A1 (0.65) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL580584 | 0.85 | ALDH1A1 (0.63) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL29355273 | 0.85 | ALDH1A1 (0.63) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL15365020 | 0.84 | CYP2C9 (0.50) | ALDH1A1TDP1TSHRCA2ATM | |
| SCHEMBL28606377 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TDP1TSHRCA2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102093684-B | Polycarbonate Alloys with highly resistance deformability and improved surface property | 科思创德国股份有限公司 | 2019-04-05 | — | — | CN | disclosed |