Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 12/20 | 0.34 |
| ▸ | FEN1 | P39748 | 10/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313597 | 0.84 | LMNA (0.42) | ALOX5APKDM4EPOLB | |
| SCHEMBL2829134 | 0.82 | CCNT1 (0.39) | LCKKITSRCKDRALOX5AP | |
| SCHEMBL313095 | 0.77 | LMNA (0.42) | KDM4EPOLB | |
| SCHEMBL313739 | 0.74 | S1PR1 (0.54) | KDM4EPOLB | |
| SCHEMBL1348445 | 0.72 | LCK (0.38) | LCKKITSRCKDRALOX5AP | |
| SCHEMBL312216 | 0.72 | S1PR1 (0.47) | KDM4EPOLB | |
| SCHEMBL1346318 | 0.70 | SCN5A (0.40) | SRCKDM4EALDH1A1 | |
| SCHEMBL313729 | 0.69 | CA9 (0.47) | KDM4EPOLB | |
| SCHEMBL312604 | 0.69 | CA2 (0.40) | KDM4EPOLB | |
| SCHEMBL1349224 | 0.67 | SCN5A (0.37) | SRCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934214-B1 | OXADIAZOLYL PYRAZOLO-PYRIMIDINES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-04-07 | — | — | EP | claimed |