Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 4/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289895 | 0.82 | HTT (0.38) | CSNK1A1CLK4ALDH1A1NPSR1TDP1 | |
| SCHEMBL20302398 | 0.77 | CSNK1A1 (0.41) | CSNK1A1CLK4ALDH1A1NPSR1TDP1 | |
| SCHEMBL3067853 | 0.74 | CSNK1A1 (0.36) | CSNK1A1CLK4ALDH1A1KDM5AKDM4C | |
| SCHEMBL3826388 | 0.73 | CSNK1A1 (0.41) | CSNK1A1CLK4ALDH1A1NPSR1TDP1 | |
| SCHEMBL23532534 | 0.71 | GLA (0.38) | ALDH1A1NPSR1KDM5AMAPK1KDM4E | |
| SCHEMBL21736899 | 0.70 | PGK1 (0.37) | CSNK1A1CLK4ALDH1A1KDM5AKDM4C | |
| SCHEMBL5200520 | 0.70 | USP7 (0.43) | CSNK1A1CLK4ALDH1A1KDM5AKDM4C | |
| SCHEMBL21736855 | 0.70 | KDM5A (0.39) | ALDH1A1KDM5AKDM4CMAPK1KDM4E | |
| SCHEMBL14554095 | 0.69 | ALDH1A1 (0.49) | CSNK1A1CLK4ALDH1A1NPSR1TDP1 | |
| SCHEMBL16884625 | 0.69 | LRRK2 (0.37) | ALDH1A1NPSR1TDP1KDM5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-A | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-02 | — | — | CN | disclosed |