Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122924 | 0.90 | P2RX7 (0.55) | SMN1; SMN2P2RX7 | |
| SCHEMBL8289085 | 0.87 | RAB9A (0.53) | SMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL13164062 | 0.86 | RAB9A (0.56) | SMN1; SMN2MAPTALDH1A1HTT | |
| SCHEMBL13164058 | 0.82 | MEN1 (0.56) | SMN1; SMN2P2RX7MAPTALDH1A1HPGD | |
| SCHEMBL14335466 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1HPGDKDM1AHTT | |
| SCHEMBL13162928 | 0.79 | L3MBTL1 (0.62) | PKMPOLBALDH1A1 | |
| SCHEMBL13164059 | 0.78 | MEN1 (0.66) | POLBALDH1A1HPGD | |
| SCHEMBL12301999 | 0.78 | CYP3A4 (0.60) | SMN1; SMN2PKMMAPTALDH1A1CYP1A2 | |
| SCHEMBL2362567 | 0.76 | POLB (0.66) | SMN1; SMN2POLBMAPTALDH1A1HPGD | |
| SCHEMBL10013747 | 0.76 | HTT (0.72) | SMN1; SMN2PKMMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104350055-B | Bicyclic heteroaryl derivatives and application thereof as MNK1 and MNK2 regulator | 新加坡科技研究局 | 2019-05-31 | — | — | CN | disclosed |