Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1525949 | 0.81 | MGLL (0.46) | ALDH1A1HIF1ACYP3A4SMN1; SMN2PPARG | |
| SCHEMBL1526072 | 0.80 | THRB (0.61) | ALDH1A1TSHRHIF1ACYP3A4SMN1; SMN2 | |
| SCHEMBL6013761 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL14239796 | 0.75 | MGLL (0.43) | ALDH1A1HIF1ACYP3A4SMN1; SMN2PPARG | |
| SCHEMBL12837225 | 0.74 | THRB (0.56) | ALDH1A1HIF1ACYP3A4SMN1; SMN2PPARG | |
| SCHEMBL1525951 | 0.74 | THRB (0.40) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL1525943 | 0.73 | EPHX2 (0.42) | ALDH1A1CYP3A4SMN1; SMN2PPARGTHRB | |
| SCHEMBL19309251 | 0.73 | THRB (0.43) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL1525910 | 0.72 | THRB (0.43) | ALDH1A1TSHRHIF1ACYP3A4SMN1; SMN2 | |
| SCHEMBL1525948 | 0.72 | THRB (0.38) | ALDH1A1TP53TSHRHIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442800-B1 | NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE, ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF | NANOPHARMACEUTICALS LLC (US) | 2019-04-24 | — | — | EP | disclosed |
| EP-2662079-A1 | Uses of formulations of thyroid hormone antagonists and nanoparticulate forms thereof to increase chemosensivity and radiosensitivity in tumor or cancer cells | Ordway Research Institute, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| WO-2010148007-A2 | NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE, ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF | ORDWAY RESEARCH INSTITUTE, INC. (US) | 2010-12-23 | — | — | WO | disclosed |