Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfanilamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.59 |
| ▸ | CA9 | Q16790 | 16/20 | 0.59 |
| ▸ | CA1 | P00915 | 16/20 | 0.59 |
| ▸ | CA12 | O43570 | 12/20 | 0.59 |
| ▸ | CA7 | P43166 | 9/20 | 0.59 |
| ▸ | CA4 | P22748 | 7/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.59 |
| ▸ | CA6 | P23280 | 5/20 | 0.59 |
| ▸ | CA5A | P35218 | 5/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.59 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.59 |
| ▸ | CA3 | P07451 | 2/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfanilamide SCHEMBL4528813 | 0.78 | CA2 (0.68) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL27586075 | 0.78 | CA2 (0.68) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL27605551 | 0.78 | CA2 (0.68) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL27696214 | 0.78 | CA2 (0.57) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL8380125 | 0.77 | CA2 (0.81) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL27911829 | 0.77 | CA2 (0.81) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL4188099 | 0.77 | CA2 (0.90) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL8449748 | 0.77 | CA2 (0.90) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL2798899 | 0.77 | CA2 (1.00) | CA2CA9CA1CA12CA7 | |
| Sulfanilamide SCHEMBL31544839 | 0.77 | CA2 (1.00) | CA2CA9CA1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748870-A | The preparation method of indenoisoquinoline derivative | 姚清发 | 2019-05-14 | — | — | CN | disclosed |