Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.90 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.90 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.84 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570908 | 0.95 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL6386658 | 0.92 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL3025457 | 0.90 | HDAC6 (0.91) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL6919516 | 0.88 | HDAC6 (0.81) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL10099575 | 0.87 | NR1H4 (0.84) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL28024624 | 0.87 | HDAC6 (0.77) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL4931363 | 0.87 | TP53 (0.79) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11900090 | 0.87 | HDAC6 (0.85) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL457082 | 0.87 | HDAC6 (0.79) | HDAC6HDAC1HDAC8HDAC2EPHX2 | |
| SCHEMBL21454774 | 0.86 | HDAC6 (0.75) | HDAC6HDAC1HDAC8HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209765-A2 | HISTONE DEACETYLASE INHIBITORS | Orchid Research Laboratories Limited (IN) | 2010-07-28 | — | — | EP | claimed |
| WO-2009053808-A2 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-04-30 | — | — | WO | claimed |
| US-20230390308-A1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2023-12-07 | — | — | US | disclosed |
| US-11833160-B2 | Ursodeoxycholic acid derivatives as HDAC inhibitors for the treatment of polycystic diseases | UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2023-12-05 | — | — | US | disclosed |
| EP-3733684-B9 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2022-05-11 | — | — | EP | disclosed |
| EP-3733684-B1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2022-01-26 | — | — | EP | disclosed |
| EP-2209765-A2 | HISTONE DEACETYLASE INHIBITORS | Orchid Research Laboratories Limited (IN) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009053808-A2 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230390308-A1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | PKD1, PKD2, SLC10A1 | HDAC6 1710/4885HDAC1 2857/4885HDAC8 3353/4885 |
| US-11833160-B2 | Ursodeoxycholic acid derivatives as HDAC inhibitors for the treatment of polycystic diseases | HDAC1, HDAC2, HDAC9 | HDAC6 5/4885HDAC1 1/4885HDAC8 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.