Kyotorphin

Kyotorphin

SCHEMBL28292

NC(N)=NCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NPY1R P25929 4/20 0.69
▸ NPY2R P49146 1/20 0.69
▸ NPY4R P50391 1/20 0.69
▸ MC4R P32245 2/20 0.59
▸ MC3R P41968 2/20 0.59
▸ NPFFR1 Q9GZQ6 2/20 0.57
▸ NPFFR2 Q9Y5X5 2/20 0.57
▸ NPY5R Q15761 2/20 0.57
▸ C3AR1 Q16581 3/20 0.53
▸ ERAP2 Q6P179 1/20 0.51
▸ ERAP1 Q9NZ08 1/20 0.51
▸ LNPEP Q9UIQ6 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D[-Arg-2]Kyotorphan Acetate SCHEMBL31332230 1.00 NPY1R (0.69) NPY1RNPY2RNPY4RMC4RMC3R
Kyotorphin SCHEMBL29516637 1.00 NPY1R (0.69) NPY1RNPY2RNPY4RMC4RMC3R
Kyotorphin SCHEMBL29966938 1.00 NPY1R (0.69) NPY1RNPY2RNPY4RMC4RMC3R
SCHEMBL29471109 0.91 MC4R (0.67) NPY1RNPY2RNPY4RMC4RMC3R
SCHEMBL29936161 0.89 NPY4R (0.69) NPY1RNPY2RNPY4RNPFFR1NPFFR2
SCHEMBL29351314 0.88 MC4R (0.65) NPY1RNPY2RNPY4RMC4RMC3R
SCHEMBL29360943 0.88 NPY1R (0.60) NPY1RNPY2RNPY4RMC4RMC3R
SCHEMBL29349984 0.85 NPY1R (0.65) NPY1RNPY2RNPY4RMC4RMC3R
SCHEMBL29350671 0.85 NPY1R (0.73) NPY1RNPY2RNPY4RERAP2ERAP1
SCHEMBL29406227 0.84 LNPEP (0.61) NPY1RNPY2RNPY4RERAP2LNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1773 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038846-A1 L-ARGININE FORMULATIONS AND METHODS OF MANAGING PAIN EMORY UNIVERSITY (US) 2025-02-20 — — WO claimed
CN-119326868-A Ginseng antler refined component and preparation method and application thereof 长春中医药大学 2025-01-21 — — CN claimed
CN-119119173-A Kyotrophin synthesis method 湖北泓肽生物科技有限公司 2024-12-13 — — CN claimed
CN-112638423-B Bioconjugates of neuropeptide derivatives 法国国家科学研究中心 2024-10-25 — — CN claimed
CN-114920851-B Aβ1-42 antigen and use thereof for detecting Aβ1-42 concentration in Alzheimer's patient 福建亿彤生物科技有限公司 2024-05-31 — — CN claimed
CN-118067865-A Quantitative detection method for middle ear cholesteatoma tissue differential markers 浙江大学 2024-05-24 — — CN claimed
CN-118032972-A Screening method of middle ear cholesteatoma bone-breaking progress related metabolites 浙江大学 2024-05-14 — — CN claimed
US-11845055-B2 Swellable organically modified silica as nanoreactors APPALACHIAN STATE UNIVERSITY (US) 2023-12-19 — — US claimed
CN-115806946-A Preparation method of kyotorphin and derivatives thereof 深圳瑞德林生物技术有限公司 2023-03-17 — — CN claimed
US-11590232-B2 Bioconjugates of neuropeptides derivatives CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2023-02-28 — — US claimed
US-5624894-A Brain-enhanced delivery of neuroactive peptides by sequential metabolism UNIVERSITY OF FLORIDA (US) 1997-04-29 — — US claimed
EP-0661986-A4 BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM. UNIV FLORIDA (US) 1997-04-23 — — EP claimed
WO-1997003652-A1 EPIDURAL ADMINISTRATION OF THERAPEUTIC COMPOUNDS WITH SUSTAINED RATE OF RELEASE DEPOTECH CORPORATION (US) 1997-02-06 — — WO claimed
EP-0709085-A1 Sustained-release preparation Takeda Chemical Industries, Ltd. (JP) 1996-05-01 — — EP claimed
EP-0661986-A1 BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM UNIVERSITY OF FLORIDA (US) 1995-07-12 — — EP claimed
WO-1994006450-A1 BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM UNIVERSTIY OF FLORIDA (US) 1994-03-31 — — WO claimed
WO-1993024150-A1 SALTS OF PEPTIDES WITH CARBOXY-TERMINATED POLYESTERS ZENECA LIMITED (GB) 1993-12-09 — — WO claimed
EP-0540631-A1 TRANS-MUCOSAL DRUG PREPARATIONS AND TRANS-MUCOSAL ADMINISTRATION Rijksuniversiteit te Leiden (NL) 1993-05-12 — — EP claimed
EP-0506032-A1 Receptor purification method AMERICAN CYANAMID COMPANY (US) 1992-09-30 — — EP claimed
WO-1992001440-A1 TRANS-MUCOSAL DRUG PREPARATIONS AND TRANS-MUCOSAL ADMINISTRATION RIJKSUNIVERSITEIT TE LEIDEN (NL) 1992-02-06 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11845055-B2 Swellable organically modified silica as nanoreactors MSN, SORD, OGA NPY1R 4768/4885NPY2R 4799/4885NPY4R 4617/4885
US-11590232-B2 Bioconjugates of neuropeptides derivatives VIP, NGLY1, NPSR1 NPY1R 42/4885NPY2R 71/4885NPY4R 112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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