Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826714 | 0.86 | GRM5 (0.70) | GRM5JAK2JAK3PORCNABL1 | |
| SCHEMBL2824785 | 0.85 | GRM5 (0.70) | GRM5NPC1RAB9AJAK2JAK3 | |
| SCHEMBL2826585 | 0.84 | GRM5 (0.52) | GRM5JAK2JAK3PORCNKMT2A | |
| SCHEMBL2827196 | 0.83 | GRM5 (0.58) | GRM5NPC1JAK2JAK3PORCN | |
| SCHEMBL2830286 | 0.83 | GRM5 (0.40) | GRM5NPC1RAB9APOLBKMT2A | |
| SCHEMBL2827578 | 0.82 | GRM5 (0.50) | GRM5NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL2828125 | 0.82 | GRM5 (0.50) | GRM5SMN1; SMN2ABL1PIK3CAPIK3CG | |
| SCHEMBL2827009 | 0.82 | GRM5 (0.53) | GRM5NPC1RAB9AJAK2JAK3 | |
| SCHEMBL2827024 | 0.81 | GRM5 (0.49) | GRM5NPC1RAB9AJAK2JAK3 | |
| SCHEMBL2827389 | 0.81 | GRM5 (0.51) | GRM5JAK2JAK3SMN1; SMN2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |