Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829312 | 0.88 | GRM5 (0.52) | GRM5CDK4CDK2NPC1RAB9A | |
| SCHEMBL2829117 | 0.86 | GRM5 (0.38) | GRM5CDK4CDK2NPC1RAB9A | |
| SCHEMBL2828101 | 0.85 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2829210 | 0.83 | GRM5 (0.54) | GRM5NPC1RAB9APOLBKMT2A | |
| SCHEMBL2826277 | 0.82 | NPC1 (0.40) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2829847 | 0.81 | GRM5 (0.52) | GRM5 | |
| SCHEMBL2825999 | 0.80 | LMNA (0.41) | GRM5NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2824577 | 0.77 | GRM5 (0.49) | GRM5CDK4CDK2NPC1RAB9A | |
| SCHEMBL2829701 | 0.76 | GRM5 (0.48) | GRM5CDK4CDK2NPC1RAB9A | |
| SCHEMBL2833088 | 0.76 | GRM5 (0.56) | GRM5KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |