Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quinolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.96 |
| ▸ | MAPT | P10636 | 2/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | AGER | Q15109 | 1/20 | 0.96 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.96 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ASPH | Q12797 | 2/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinolinic Acid SCHEMBL7734169 | 1.00 | KDM4E (0.96) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL890369 | 1.00 | KDM4E (0.96) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL10414968 | 0.98 | KDM4E (0.92) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL10414442 | 0.98 | KDM4E (0.92) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL10414969 | 0.98 | KDM4E (0.92) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL29356188 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL69230 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL27676801 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL343618 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1ALOX15MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL3744925 | 0.96 | KDM4E (0.96) | KDM4EALDH1A1ALOX15MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116660424-A | Method for detecting quinclorac in honey | 秦皇岛海关技术中心 | 2023-08-29 | — | — | CN | claimed |
| US-20240335796-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | THE PENN STATE RESEARCH FOUNDATION | 2024-10-10 | — | — | US | disclosed |
| US-12036515-B2 | Thin-film composite membrane and methods of making and using the same | THE PENN STATE RESEARCH FOUNDATION (PA) | 2024-07-16 | — | — | US | disclosed |
| US-20210370240-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | THE PENN STATE RESEARCH FOUNDATION | 2021-12-02 | — | — | US | disclosed |
| EP-3860743-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | The Penn State Research Foundation (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-111315732-A | Pyrazine-4-carbamate or-urea derivatives as herbicides | 先正达参股股份有限公司 | 2020-06-19 | — | — | CN | disclosed |
| WO-2020072594-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2020-04-09 | — | — | WO | disclosed |
| EP-2788108-A1 | MEMBRANE, WATER TREATMENT SYSTEM, AND METHOD OF MAKING | General Electric Company (US) | 2014-10-15 | — | — | EP | disclosed |
| US-8591741-B2 | Thin film composite membranes incorporating carbon nanotubes | GENERAL ELECTRIC COMPANY (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2621614-A1 | THIN FILM COMPOSITE MEMBRANES INCORPORATING CARBON NANOTUBES | General Electric Company (US) | 2013-08-07 | — | — | EP | disclosed |
| US-20120080381-A1 | THIN FILM COMPOSITE MEMBRANES INCORPORATING CARBON NANOTUBES | GENERAL ELECTRIC COMPANY (US) | 2012-04-05 | — | — | US | disclosed |
| US-20120080380-A1 | THIN FILM COMPOSITE MEMBRANES INCORPORATING CARBON NANOTUBES | GENERAL ELECTRIC COMPANY (US) | 2012-04-05 | — | — | US | disclosed |
| US-20110168631-A1 | METHODS AND APPARATUSES FOR WATER FILTRATION USING POLYARYLETHER MEMBRANES | GENERAL ELECTRIC COMPANY (US) | 2011-07-14 | — | — | US | disclosed |
| EP-2259865-A1 | AROMATIC HALSULFONYL ISOCYANATE COMPOSITIONS AND POLYMERS THEREFROM | General Electric Company (US) | 2010-12-15 | — | — | EP | disclosed |
| US-7727434-B2 | Membranes and methods of treating membranes | GENERAL ELECTRIC COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090242831-A1 | AROMATIC HALOSULFONYL ISOCYANATE COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090242479-A1 | AROMATIC HALOSULFONYL ISOCYANATE COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2009-10-01 | — | — | US | disclosed |
| WO-2009120492-A1 | AROMATIC HALSULFONYL ISOCYANATE COMPOSITIONS AND POLYMERS THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20070039874-A1 | Membranes and methods of treating membranes | GENERAL ELECTRIC COMPANY | 2007-02-22 | — | — | US | disclosed |
| US-5693227-A | POLYMERIZATION OF MOLECULES HAVING ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUENTS ON THE SAME OR DIFFERENT MOLECULES; REGENERATION OF AMINOPYRIDINE CATALYSTS | IONICS, INCORPORATED (US) | 1997-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240335796-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | PORCN, MLEC, FLOT1 | GAA 4229/4885KDM4E 3071/4885ALDH1A1 4875/4885 |
| US-12036515-B2 | Thin-film composite membrane and methods of making and using the same | PORCN, MLEC, FLOT1 | GAA 4229/4885KDM4E 3071/4885ALDH1A1 4875/4885 |
| US-20090242831-A1 | AROMATIC HALOSULFONYL ISOCYANATE COMPOSITIONS | H1-10, INCENP, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | GAA 4875/4885KDM4E 850/4885ALDH1A1 1990/4885 |
| US-20210370240-A1 | THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME | PORCN, MLEC, FLOT1 | GAA 4229/4885KDM4E 3071/4885ALDH1A1 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.