Pyrene

Pyrene

SCHEMBL28292596

O=[N+]([O-])c1ccc2ccc3c([N+](=O)[O-])cc([N+](=O)[O-])c4ccc1c2c34.c1cc2ccc3cccc4ccc(c1)c2c34

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 1/20 0.51
ALDH1A1 P00352 8/20 0.50
CYP3A4 P08684 5/20 0.47
HSD17B10 Q99714 3/20 0.47
ALOX15 P16050 1/20 0.47
TDP1 Q9NUW8 3/20 0.47
TSHR P16473 3/20 0.45
KMT2A Q03164 4/20 0.42
RAB9A P51151 3/20 0.42
MEN1 O00255 3/20 0.42
NPC1 O15118 2/20 0.42
GAA P10253 2/20 0.42
CYP1A2 P05177 3/20 0.42
ERBB2 P04626 1/20 0.42
FYN P06241 1/20 0.42
MAOA P21397 1/20 0.42
ACHE P22303 1/20 0.42
AHR P35869 1/20 0.42
MAPT P10636 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3293306 0.95 HPRT1 (0.56) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL28796982 0.93 HPRT1 (0.51) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL29403406 0.93 HPRT1 (0.49) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL339725 0.93 ALDH1A1 (0.57) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL29450697 0.93 ALDH1A1 (0.57) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL16593674 0.93 HPRT1 (0.49) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28378090 0.91 ALDH1A1 (0.55) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL28796978 0.90 HPRT1 (0.56) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28892009 0.89 ALDH1A1 (0.53) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28624685 0.88 ALDH1A1 (0.52) HPRT1ALDH1A1CYP3A4HSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109734078-A A kind of preparation method of yellow-green fluorescence graphene quantum dot 泉州师范学院 2019-05-10 CN claimed
CN-109734078-A A kind of preparation method of yellow-green fluorescence graphene quantum dot 泉州师范学院 2019-05-10 CN disclosed