1-Nitropyrene

1-Nitropyrene

SCHEMBL29450697

O=[N+]([O-])c1ccc2ccc3cccc4ccc1c2c34

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.57
TDP1 Q9NUW8 4/20 0.54
CYP3A4 P08684 4/20 0.53
HSD17B10 Q99714 4/20 0.53
ALOX15 P16050 1/20 0.53
HPRT1 P00492 1/20 0.49
KMT2A Q03164 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
GAA P10253 2/20 0.46
MEN1 O00255 2/20 0.46
HPGD P15428 4/20 0.45
TSHR P16473 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
CTSB P07858 1/20 0.44
CYP1A2 P05177 4/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1B1 Q16678 1/20 0.44
KDM4E B2RXH2 2/20 0.43
MAPT P10636 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Nitropyrene SCHEMBL339725 1.00 ALDH1A1 (0.57) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28378090 0.98 ALDH1A1 (0.55) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28892009 0.96 ALDH1A1 (0.53) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL28624685 0.94 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
Pyrene SCHEMBL28292596 0.93 HPRT1 (0.51) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
SCHEMBL29450698 0.92 TDP1 (0.50) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
SCHEMBL1804954 0.92 TDP1 (0.50) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
SCHEMBL967910 0.92 TDP1 (0.50) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
1-Nitropyrene SCHEMBL8019945 0.90 ALDH1A1 (0.47) ALDH1A1TDP1CYP3A4HSD17B10ALOX15
SCHEMBL28796982 0.89 HPRT1 (0.51) ALDH1A1TDP1CYP3A4HSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250268926-A1 METHOD AND COMPOSITION FOR TREATING, ALLEVIATING OR PREVENTING A DISEASE OR CONDITION CAUSED BY AIR POLLUTANT HONG KONG BAPTIST UNIVERSITY (CN) 2025-08-28 US disclosed
WO-2025124901-A1 PROCESS FOR PRODUCING PURIFIED CARBON BLACKS WITH REDUCED CONTENT OF OXIDIZED POLYCYCLIC AROMATIC HYDROCARBONS ORION ENGINEERED CARBONS IP GMBH & CO. KG (DE) 2025-06-19 WO disclosed
WO-2025098667-A1 ALKALINE CARBON BLACK, PREPARATION THEREOF AND COMPOSITIONS AND ARTICLES CONTAINING THE SAME ORION ENGINEERED CARBONS IP GMBH & CO. KG (DE) 2025-05-15 WO disclosed
CN-119864417-A Application method of multi-active-point pyrenyl fused ring compound in primary battery 南开大学 2025-04-22 CN disclosed
CN-119334920-A Method for detecting content change of E-DOM and I-DOM released by algae under exposure of PAHs and derivatives thereof 厦门大学 2025-01-21 CN disclosed
EP-3653573-B1 SURFACE-MODIFIED INORGANIC NITRIDE, COMPOSITION, THERMALLY CONDUCTIVE MATERIAL, DEVICE PROVIDED WITH THERMALLY CONDUCTIVE LAYER FUJIFILM CORP (JP) 2024-08-14 EP disclosed
EP-3443055-B1 REMOVING AROMATIC COMPOUNDS FROM A HYDROCARBON FLUID CASTROL LTD (GB) 2024-07-03 EP disclosed
EP-4263724-A1 PROCESS FOR PRODUCING CARBON BLACKS WITH REDUCED POLYCYCLIC AROMATIC HYDROCARBON CONTENT UTILIZING SUPERCRITICAL FLUID EXTRACTION Orion Engineered Carbons IP GmbH & Co. KG (DE) 2023-10-25 EP disclosed
EP-3507823-B1 CAPACITORS, ELECTRODES, REDUCED GRAPHENE OXIDE AND METHODS AND APPARATUSES OF MANUFACTURE UNIV SWINBURNE TECHNOLOGY (AU) 2023-03-22 EP disclosed
CN-114324681-A High-throughput method for detecting content of nitro polycyclic aromatic hydrocarbon 南通市疾病预防控制中心 2022-04-12 CN disclosed