Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829117 | 0.86 | GRM5 (0.38) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2830286 | 0.85 | GRM5 (0.40) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2825999 | 0.85 | LMNA (0.41) | GRM5SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL2829267 | 0.85 | GRM5 (0.55) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2829847 | 0.84 | GRM5 (0.52) | GRM5 | |
| SCHEMBL2829312 | 0.84 | GRM5 (0.52) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2824785 | 0.83 | GRM5 (0.70) | GRM5RAB9ANPC1 | |
| SCHEMBL2826277 | 0.83 | NPC1 (0.40) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2824577 | 0.80 | GRM5 (0.49) | GRM5SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2826867 | 0.78 | CDK4 (0.45) | GRM5SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |