SCHEMBL28292903

SCHEMBL28292903

COc1ccc(-c2cc(C(=O)N3CCOCC3)nn2-c2ccc(S(N)(=O)=O)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 18/20 1.00
CHRNA7 P36544 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28292892 0.90 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28872794 0.90 PTGS2 (1.00) PTGS2
SCHEMBL28292890 0.89 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28292908 0.89 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28872997 0.87 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28292886 0.87 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28292993 0.87 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL28294500 0.85 PTGS2 (1.00) PTGS2CHRNA7
SCHEMBL6351220 0.83 CHRNA7 (0.78) PTGS2CHRNA7
SCHEMBL27554183 0.83 CHRNA7 (0.78) PTGS2CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109748872-A The design and synthesis of the morpholine derivative antitumoral compounds of one kind skeleton containing diaryl pyrazole 南京大学 2019-05-14 CN disclosed