Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585868 | 0.73 | POLB (0.41) | MEN1KMT2AHTTTSHRPOLB | |
| SCHEMBL2911565 | 0.68 | SLC18A3 (0.39) | MEN1KMT2AHTTTSHRPOLB | |
| SCHEMBL16970805 | 0.68 | RIPK1 (0.41) | MEN1KMT2AHTTTSHRPOLB | |
| SCHEMBL2908423 | 0.68 | KMT2A (0.40) | MEN1KMT2AHTTTSHRPOLB | |
| SCHEMBL6248838 | 0.68 | DRD2 (0.44) | POLBRIPK1SMN1; SMN2HRH3SLC18A3 | |
| SCHEMBL1379285 | 0.67 | KMT2A (0.42) | KMT2APOLBMTNR1BTDP1ALDH1A1 | |
| SCHEMBL27743375 | 0.66 | POLB (0.40) | TSHRPOLBRIPK1HRH3ALDH1A1 | |
| SCHEMBL2844979 | 0.66 | GBA1 (0.38) | MEN1KMT2APOLBRIPK1LMNA | |
| SCHEMBL31357052 | 0.66 | HCRTR2 (0.42) | LMNA | |
| SCHEMBL2913724 | 0.65 | POLB (0.42) | MEN1KMT2AHTTTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641886-A | bicyclic BET bromodomain inhibitors and uses thereof | 康威基内有限公司 | 2019-04-16 | — | — | CN | disclosed |