Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Methylpiperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 known ✓ | Q09470 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL28145828 | 0.81 | MAPT (0.68) | CYP2D6ALDH1A1MAPTKMT2ALMNA | |
| Dalfampridine SCHEMBL28071149 | 0.80 | ADRB2 (0.46) | CYP2D6ALDH1A1MAPTKMT2ALMNA | |
| Dalfampridine SCHEMBL28141942 | 0.80 | ADRB2 (0.46) | CYP2D6ALDH1A1MAPTKMT2ALMNA | |
| Methylpiperazine SCHEMBL28330707 | 0.78 | ACVR1 (0.47) | CYP2D6ALDH1A1TSHRADRB2NCF1 | |
| 4-Aminophenol SCHEMBL27666995 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPTKMT2ALMNACYP3A4 | |
| Dalfampridine SCHEMBL28843640 | 0.76 | GSK3B (0.43) | CYP2D6ALDH1A1MAPTKMT2ALMNA | |
| Methylpiperazine SCHEMBL28076386 | 0.75 | PLD1 (0.42) | CYP2D6ALDH1A1TSHRADRB2NCF1 | |
| Methylpiperazine SCHEMBL28280517 | 0.74 | PLD1 (0.41) | CYP2D6ALDH1A1TSHRADRB2NCF1 | |
| Sulfanilamide SCHEMBL6199910 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KMT2ALMNAMEN1TSHR | |
| Methylpiperazine SCHEMBL4779540 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641886-A | bicyclic BET bromodomain inhibitors and uses thereof | 康威基内有限公司 | 2019-04-16 | — | — | CN | disclosed |