Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | VNN1 | O95497 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825726 | 0.87 | RXRA (0.49) | SRD5A2BRAFCYP2C9 | |
| SCHEMBL29537057 | 0.87 | RXRA (0.49) | SRD5A2BRAFCYP2C9 | |
| SCHEMBL15948892 | 0.83 | BRAF (0.48) | BRAFMAPTCYP2C9LMNA | |
| SCHEMBL827199 | 0.82 | BRAF (0.46) | BRAFCYP2C9 | |
| SCHEMBL15946924 | 0.82 | ACHE (0.50) | BRAFCYP2C9 | |
| SCHEMBL29448779 | 0.82 | PARP1 (0.49) | BRAFCYP2C9 | |
| SCHEMBL16380694 | 0.82 | PARP1 (0.49) | BRAFCYP2C9 | |
| SCHEMBL11209428 | 0.82 | ATM (0.47) | ATMTDP1L3MBTL1SRD5A2VNN1 | |
| SCHEMBL13459285 | 0.81 | BRAF (0.41) | BRAFCYP2C9 | |
| SCHEMBL3684740 | 0.81 | ATM (0.63) | ATMTDP1L3MBTL1SRD5A2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444398-B | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-116554017-A | Three-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116444361-A | Six-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116444398-A | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-109651155-B | Ketone ibuprofen intermediate and preparation method and application thereof | 浙江瑞博制药有限公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-110857269-A | Ketone ibuprofen intermediate and preparation method and application thereof | 江苏瑞科医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-109651155-A | Ketone ibuprofen intermediate and preparation method and application thereof | 浙江瑞博制药有限公司 | 2019-04-19 | — | — | CN | disclosed |