Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 5/20 | 0.40 |
| ▸ | FPR1 | P21462 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828691 | 0.86 | PDE4B (0.42) | TRPV1PDE4BPKMMEN1KMT2A | |
| SCHEMBL2829404 | 0.86 | PDE4B (0.39) | FPR2FPR1PDE4BPKMPOLB | |
| SCHEMBL2829346 | 0.84 | KDM4C (0.36) | FPR2FPR1PDE4BSMN1; SMN2 | |
| SCHEMBL2829191 | 0.83 | PDE4B (0.39) | PDE4BPKMMEN1KMT2ATBXAS1 | |
| SCHEMBL2826523 | 0.82 | MAPT (0.45) | SORT1LRRK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2828384 | 0.80 | SMN1; SMN2 (0.38) | TRPV1PDE4BPOLBMEN1KMT2A | |
| SCHEMBL2828832 | 0.78 | PDE4B (0.43) | TRPV1PDE4BPOLBMEN1KMT2A | |
| SCHEMBL2828120 | 0.77 | KDM4C (0.38) | PDE4BMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1997905 | 0.75 | PDE4B (0.47) | FPR2FPR1TRPV1PDE4BPKM | |
| SCHEMBL2825329 | 0.74 | PDE4B (0.40) | TRPV1PDE4BPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |