Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 2/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826438 | 0.87 | GPR52 (0.39) | MAPTGPR52CHEK1DAPK3ROCK2 | |
| SCHEMBL2829407 | 0.82 | FPR2 (0.40) | LRRK2MEN1KMT2ASORT1SMN1; SMN2 | |
| SCHEMBL2829411 | 0.82 | TRPV1 (0.43) | MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2828691 | 0.81 | PDE4B (0.42) | MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2829191 | 0.79 | PDE4B (0.39) | MAPTMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL2829404 | 0.78 | PDE4B (0.39) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2000162 | 0.77 | MAPT (0.44) | MAPTKIF11UBE2MDCUN1D1LRRK2 | |
| SCHEMBL2828832 | 0.74 | PDE4B (0.43) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2828120 | 0.73 | KDM4C (0.38) | MAPTMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL2829015 | 0.73 | ALDH1A1 (0.46) | MAPTMEN1KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |