Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828691 | 0.86 | PDE4B (0.42) | PDE4BALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2829404 | 0.84 | PDE4B (0.39) | PDE4BALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL2829407 | 0.83 | FPR2 (0.40) | PDE4BMEN1KMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL2826523 | 0.79 | MAPT (0.45) | MEN1KMT2ASMN1; SMN2TSHRMAPT | |
| SCHEMBL2828832 | 0.78 | PDE4B (0.43) | PDE4BALDH1A1MEN1KMT2ATBXAS1 | |
| SCHEMBL1997905 | 0.75 | PDE4B (0.47) | PDE4BALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2825329 | 0.74 | PDE4B (0.40) | PDE4BALDH1A1MEN1KMT2ATBXAS1 | |
| SCHEMBL4050108 | 0.74 | PDE4B (0.63) | PDE4BALDH1A1LMNAMAPK1TBXAS1 | |
| SCHEMBL2001351 | 0.74 | NPC1 (0.43) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1997288 | 0.74 | PDE4B (0.46) | PDE4BALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |