Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941116 | 1.00 | SCN9A (0.40) | SCN9AFPR2LRRK2MEN1KMT2A | |
| SCHEMBL28941054 | 1.00 | SCN9A (0.40) | SCN9AFPR2LRRK2MEN1KMT2A | |
| SCHEMBL28872982 | 0.78 | SMN1; SMN2 (0.62) | SCN9ASMN1; SMN2MTOR | |
| SCHEMBL28941055 | 0.77 | NTRK1 (0.41) | LRRK2MEN1KMT2ASMN1; SMN2PDK1 | |
| SCHEMBL28294291 | 0.77 | NTRK1 (0.41) | LRRK2MEN1KMT2ASMN1; SMN2PDK1 | |
| SCHEMBL28941108 | 0.77 | NTRK1 (0.41) | LRRK2MEN1KMT2ASMN1; SMN2PDK1 | |
| SCHEMBL28292565 | 0.76 | L3MBTL1 (0.49) | SMN1; SMN2PDK1NTRK1HCRTR1HCRTR2 | |
| SCHEMBL28941103 | 0.75 | SCN9A (0.49) | SCN9ALRRK2KMT2ASMN1; SMN2PDK1 | |
| SCHEMBL28941076 | 0.75 | SCN9A (0.49) | SCN9ALRRK2KMT2ASMN1; SMN2PDK1 | |
| SCHEMBL28940980 | 0.72 | SCN9A (0.48) | SCN9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |