Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 3/20 | 0.42 |
| ▸ | KDM6B | O15054 | 2/20 | 0.42 |
| ▸ | KDM5C | P41229 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21572840 | 0.87 | KDM4E (0.55) | KDRBRAFEPHX2RAF1FTO | |
| SCHEMBL19439121 | 0.82 | BRD4 (0.50) | KDRBRAFEPHX2RAF1FTO | |
| SCHEMBL29831137 | 0.82 | BRD4 (0.50) | KDRBRAFEPHX2RAF1FTO | |
| SCHEMBL6388163 | 0.82 | JMJD7 (0.55) | KDM4EKDM5CKDM4CALDH1A1MAPT | |
| SCHEMBL28255652 | 0.82 | RAF1 (0.44) | KDRBRAFEPHX2RAF1FTO | |
| Hydrochloric Acid SCHEMBL28255649 | 0.81 | BRD4 (0.49) | KDRBRAFEPHX2RAF1FTO | |
| SCHEMBL19439262 | 0.80 | FTO (0.67) | KDRBRAFFTOKDM4EALKBH5 | |
| SCHEMBL29830791 | 0.80 | FTO (0.67) | KDRBRAFFTOKDM4EALKBH5 | |
| SCHEMBL28294252 | 0.76 | MAPK1 (0.56) | KDM4EALDH1A1MAPTNPC1LMNA | |
| SCHEMBL2642841 | 0.75 | KDR (0.46) | KDRBRAFEPHX2RAF1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |