Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | KDM6B | O15054 | 2/20 | 0.55 |
| ▸ | KDM5C | P41229 | 2/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28294296 | 0.87 | KDR (0.44) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30065796 | 0.86 | KDM4E (0.62) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL70350 | 0.86 | KDM4E (0.62) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL6388163 | 0.84 | JMJD7 (0.55) | KDM4EKDM5CKDM4CALOX15L3MBTL1 | |
| SCHEMBL28255652 | 0.84 | RAF1 (0.44) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL29830791 | 0.83 | FTO (0.67) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30378954 | 0.83 | KDM4E (0.58) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30779113 | 0.83 | KDM4E (0.68) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL475565 | 0.83 | KDM4E (0.68) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL1759313 | 0.83 | KDM4E (0.58) | KDM4EKDM6BKDM5CKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2023-07-06 | — | — | US | disclosed |
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2023-07-06 | — | — | US | disclosed |
| US-11059836-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-10479802-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | KDM4E 4585/4885KDM6B 4697/4885KDM5C 4770/4885 |
| US-10479802-B2 | Probes for imaging huntingtin protein | HTT, HYPK, FABP7 | KDM4E 4674/4885KDM6B 4714/4885KDM5C 4827/4885 |
| US-11059836-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | KDM4E 4585/4885KDM6B 4697/4885KDM5C 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.