Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292584 | 0.92 | SCN9A (0.46) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28292616 | 0.92 | SCN9A (0.46) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28292599 | 0.85 | KMT2A (0.52) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28940974 | 0.85 | KMT2A (0.52) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28292628 | 0.85 | KMT2A (0.52) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28872982 | 0.83 | SMN1; SMN2 (0.62) | HRH3SCN9ADRD3NPC1RAB9A | |
| SCHEMBL28940980 | 0.82 | SCN9A (0.48) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL28294359 | 0.82 | SCN9A (0.48) | HRH3KCNH2L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL31262623 | 0.76 | L3MBTL1 (0.50) | HRH3KCNH2L3MBTL3L3MBTL1SCN9A | |
| SCHEMBL20254511 | 0.76 | L3MBTL1 (0.50) | HRH3KCNH2L3MBTL3L3MBTL1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |