Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 13/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424941 | 0.97 | RAPGEF4 (0.55) | RAPGEF4FFAR4ALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL1013011 | 0.95 | RAPGEF4 (0.52) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL19367695 | 0.82 | RAPGEF4 (0.55) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL14587753 | 0.82 | RAPGEF4 (0.55) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL2354467 | 0.78 | RAPGEF4 (0.50) | RAPGEF4FFAR4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29113098 | 0.76 | RAPGEF4 (0.48) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL29113095 | 0.73 | RAPGEF4 (0.44) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL2775070 | 0.72 | ALDH1A1 (0.46) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL11177259 | 0.72 | RAPGEF4 (0.43) | RAPGEF4FFAR4ALDH1A1 | |
| SCHEMBL2775069 | 0.72 | ALDH1A1 (0.46) | RAPGEF4FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109862963-A | SYNTHESIS AND CHARACTERIZATION OF RU ALKYLIDENE COMPLEXES | 优美科股份公司及两合公司 | 2019-06-07 | — | — | CN | disclosed |