Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830058 | 0.90 | LMNA (0.50) | LMNAHTTMAPTNPC1MEN1 | |
| SCHEMBL2827687 | 0.88 | MEN1 (0.49) | LMNAHTTMAPTNPC1MEN1 | |
| SCHEMBL2831112 | 0.87 | IRAK4 (0.46) | LMNAHTTGRM5MAPTKMT2A | |
| SCHEMBL2829501 | 0.84 | GRM5 (0.45) | LMNAHTTNOTUMGRM5MEN1 | |
| SCHEMBL2826420 | 0.84 | LMNA (0.47) | LMNAHTTMAPTNPC1MEN1 | |
| SCHEMBL17685492 | 0.83 | MEN1 (0.50) | LMNANOTUMGRM5MAPTPOLB | |
| SCHEMBL2826781 | 0.82 | GRM5 (0.52) | LMNANOTUMGRM5MAPTPOLB | |
| SCHEMBL2829161 | 0.82 | HPGD (0.50) | LMNAHTTMAPTNPC1MEN1 | |
| SCHEMBL2828556 | 0.81 | MAOB (0.46) | LMNAHTTMAPTNPC1MEN1 | |
| SCHEMBL2829084 | 0.80 | HPGD (0.48) | LMNAHTTMAPTNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |