Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 5/20 | 0.33 |
| ▸ | SNCA | P37840 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519850 | 0.99 | PDGFRB (0.42) | PDGFRBALDH1A1TSHRHTR7INSR | |
| Hydrochloric Acid SCHEMBL28166077 | 0.97 | PDGFRB (0.41) | PDGFRBALDH1A1TSHRHTR7INSR | |
| SCHEMBL28924615 | 0.76 | PDGFRB (0.36) | PDGFRBALDH1A1TSHRHTR7MEN1 | |
| SCHEMBL30160329 | 0.76 | PDGFRB (0.36) | PDGFRBALDH1A1TSHRHTR7MEN1 | |
| SCHEMBL21970993 | 0.71 | PDGFRB (0.43) | PDGFRBALDH1A1TSHRHTR7SNCA | |
| SCHEMBL11515562 | 0.69 | NPSR1 (0.34) | KMT2A | |
| SCHEMBL30542467 | 0.69 | NPSR1 (0.34) | KMT2A | |
| SCHEMBL11516459 | 0.68 | SNCA (0.44) | PDGFRBALDH1A1TSHRHTR7APP | |
| SCHEMBL9307101 | 0.67 | AADAT (0.34) | SMN1; SMN2TDP1TP53 | |
| SCHEMBL4625857 | 0.67 | ALOX5 (0.41) | ALDH1A1HTR7ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109642153-A | Chemiluminescent substrate | 拜克门寇尔特公司 | 2019-04-16 | — | — | CN | disclosed |