Quinoline

Quinoline

SCHEMBL28295243

CCc1ccccc1NC=O.c1ccc2ncccc2c1

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.49
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
POLB P06746 4/20 0.39
CCNB2 O95067 1/20 0.38
CDK1 P06493 1/20 0.38
RET P07949 1/20 0.38
CCNB1 P14635 1/20 0.38
CCNB3 Q8WWL7 1/20 0.38
RAB9A P51151 3/20 0.37
NPC1 O15118 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPT P10636 1/20 0.37
PTK2 Q05397 1/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.36
HDAC3 O15379 1/20 0.36
FPR1 P21462 1/20 0.36
SLC40A1 Q9NP59 1/20 0.36
SGMS2 Q8NHU3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33525287 0.81 ALDH1A1 (0.46) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL2243716 0.81 ALDH1A1 (0.46) ALDH1A1MEN1KMT2APOLBMAPT
Quinoline SCHEMBL6808379 0.76 ALDH1A1 (0.65) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL27851343 0.74 ALDH1A1 (0.74) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL27789588 0.74 ALDH1A1 (0.74) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL28250556 0.74 ALDH1A1 (0.74) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL2535469 0.74 ALDH1A1 (0.81) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL27839284 0.73 ALDH1A1 (0.65) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL28096623 0.72 ALDH1A1 (0.77) ALDH1A1MEN1KMT2APOLBRAB9A
Quinoline SCHEMBL4599170 0.72 ALDH1A1 (0.77) ALDH1A1MEN1KMT2APOLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109896987-A The preparation method of Glimepiride EP impurity D and EP impurity I 山东新华制药股份有限公司 2019-06-18 CN claimed