SCHEMBL28295532

SCHEMBL28295532

COc1ccc(-c2nc(C(=O)NCCO)c(C)o2)cc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 7/20 0.62
PDCD4 Q53EL6 1/20 0.62
MAPT P10636 6/20 0.54
KDM4E B2RXH2 4/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
ALDH1A1 P00352 3/20 0.53
LMNA P02545 2/20 0.53
HSD17B10 Q99714 1/20 0.52
ACR P10323 1/20 0.51
GAA P10253 1/20 0.50
TSHR P16473 1/20 0.50
IKBKB O14920 1/20 0.50
TP53 P04637 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11623824 0.85 KDM4E (0.60) TARBP2MAPTKDM4EMEN1KMT2A
SCHEMBL6384893 0.79 TARBP2 (0.71) TARBP2PDCD4MAPTKDM4EMEN1
Hydrochloric Acid SCHEMBL6386301 0.78 TARBP2 (0.69) TARBP2PDCD4MAPTKDM4EMEN1
SCHEMBL6386298 0.78 TARBP2 (0.69) TARBP2PDCD4MAPTKDM4EMEN1
SCHEMBL11621817 0.78 KDM4E (0.57) TARBP2MAPTKDM4EMEN1KMT2A
SCHEMBL3535824 0.77 TARBP2 (1.00) TARBP2PDCD4MAPTKDM4EMEN1
SCHEMBL28295544 0.76 TARBP2 (0.74) TARBP2PDCD4MAPTKDM4EMEN1
SCHEMBL11625061 0.74 TARBP2 (0.64) TARBP2PDCD4MAPTKDM4EMEN1
SCHEMBL28062090 0.73 KDM4E (0.58) TARBP2MAPTKDM4EMEN1KMT2A
SCHEMBL21653077 0.73 TARBP2 (0.55) TARBP2PDCD4MAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109810071-A A kind of miRNA biosynthesis inhibitor 中国科学院成都生物研究所 2019-05-28 CN disclosed