SCHEMBL3535824

SCHEMBL3535824

CCOC(=O)c1nc(-c2ccc(OC)cc2)oc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 7/20 1.00
PDCD4 Q53EL6 1/20 1.00
POLB P06746 2/20 0.54
GAA P10253 2/20 0.54
IKBKB O14920 1/20 0.54
KDM4E B2RXH2 5/20 0.53
ALDH1A1 P00352 4/20 0.53
KMT2A Q03164 2/20 0.53
HPGD P15428 2/20 0.53
HSD17B10 Q99714 2/20 0.53
TDP1 Q9NUW8 1/20 0.51
MAPT P10636 5/20 0.51
LMNA P02545 2/20 0.51
MEN1 O00255 1/20 0.50
GABRA2 P47869 1/20 0.49
GABRB2 P47870 1/20 0.49
HTT P42858 1/20 0.49
MAPK10 P53779 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28873241 0.88 TARBP2 (0.79) TARBP2PDCD4POLBGAAIKBKB
SCHEMBL4918154 0.87 TARBP2 (1.00) TARBP2PDCD4POLBIKBKBKDM4E
SCHEMBL28297242 0.87 TARBP2 (1.00) TARBP2PDCD4POLBGAAIKBKB
SCHEMBL7907774 0.86 TARBP2 (0.82) TARBP2PDCD4POLBKDM4EALDH1A1
SCHEMBL17768259 0.86 TARBP2 (0.82) TARBP2PDCD4POLBKDM4EALDH1A1
SCHEMBL13771095 0.86 TARBP2 (0.84) TARBP2PDCD4POLBGAAIKBKB
SCHEMBL18004097 0.86 TARBP2 (0.75) TARBP2PDCD4POLBKDM4EALDH1A1
SCHEMBL5192166 0.86 TARBP2 (0.75) TARBP2PDCD4POLBGAAIKBKB
SCHEMBL3539144 0.86 TARBP2 (0.84) TARBP2PDCD4POLBGAAIKBKB
SCHEMBL28295544 0.85 TARBP2 (0.74) TARBP2PDCD4POLBGAAIKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106616029-B Feed additive for improving disease resistance of rainbow trout and preparation method thereof 西南大学 2020-05-01 CN claimed
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF EPIVARIO INC (US) 2026-03-26 US disclosed
US-12441689-B2 ACSS2 inhibitors and methods of use thereof EPIVARIO, INC. (US) 2025-10-14 US disclosed
CN-109810071-B miRNA biosynthesis inhibitor 中国科学院成都生物研究所 2023-04-21 CN disclosed
US-20230084752-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF METABOMED LTD. (IL) 2023-03-16 US disclosed
EP-3969439-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF Metabomed Ltd (IL) 2022-03-23 EP disclosed
CN-114127049-A ACSS2 inhibitors and methods of use thereof 美特波米德有限公司 2022-03-01 CN disclosed
WO-2020230134-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF METABOMED LTD (IL) 2020-11-19 WO disclosed
WO-2020230134-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF METABOMED LTD (IL) 2020-11-19 WO disclosed
CN-106578707-B Immunity-improving feed for rainbow trout 西南大学 2020-07-24 CN disclosed
EP-1430039-A2 ARYL DERIVATIVES FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS Aryx Therapeutics (US) 2004-06-23 EP disclosed
US-6680387-B2 USING THIAZOLIDINONE COMPOUND ARYX THERAPEUTICS 2004-01-20 US disclosed
US-20030236227-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis ARYX THERAPEUTICS 2003-12-25 US disclosed
US-20030064972-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC 2003-04-03 US disclosed
WO-2003024943-A2 ARYL DERIVATIVES FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS ARYX THERAPEUTICS (US) 2003-03-27 WO disclosed
US-20030027798-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC 2003-02-06 US disclosed
US-5002960-A Viricides for combating picornaviruses STERLING DRUG, INC. (US) 1991-03-26 US disclosed
US-4990595-A Process for lowering the melt viscosity of aromatic polycarbonates, aromatic polyester carbonates and aromatic and/or araliphatic polyesters with super-critical gases BAYER AKTIENGESELLSCHAFT (DE) 1991-02-05 US disclosed
US-4939267-A Viricides STERLING DRUG INC. (US) 1990-07-03 US disclosed
US-4843087-A OXAZOLINYL COMPOUNDS; RHINOVIRUSES AND PICORNAVIRUSES STERLING DRUG INC. (US) 1989-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236227-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis LIPA, LIPC, CETP TARBP2 3124/4885PDCD4 4730/4885POLB 2775/4885
US-20230084752-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, ADSS2, GLS2 TARBP2 1563/4885PDCD4 903/4885POLB 1997/4885
US-20030064972-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis LIPA, LIPC, CETP TARBP2 3124/4885PDCD4 4730/4885POLB 2775/4885
US-20260085048-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, GLS2, ACSL3 TARBP2 2276/4885PDCD4 2075/4885POLB 1877/4885
US-20030027798-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis LIPA, LIPC, CETP TARBP2 3124/4885PDCD4 4730/4885POLB 2775/4885
US-12441689-B2 ACSS2 inhibitors and methods of use thereof ACSS2, ADSS2, GLS2 TARBP2 1563/4885PDCD4 903/4885POLB 1997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.