Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAP2K3 | P46734 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.46 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351486 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2DYRK1APIM1 | |
| SCHEMBL29860539 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2DYRK1APIM1 | |
| SCHEMBL28384025 | 0.87 | ALDH1A1 (0.95) | ALDH1A1MAPTSMN1; SMN2DYRK1APIM1 | |
| SCHEMBL2804132 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1759326 | 0.79 | ALDH1A1 (0.72) | ALDH1A1MAPTSMN1; SMN2DYRK1APIM1 | |
| SCHEMBL4101721 | 0.79 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL43146 | 0.79 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2PIM1KDM4E | |
| SCHEMBL30643071 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3574871 | 0.78 | TDP1 (0.54) | ALDH1A1MAPTSMN1; SMN2DYRK1AKDM4E | |
| SCHEMBL9357074 | 0.78 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2DYRK1APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689656-A | 7-substituted 1-arylnaphthyridine-3-carboxamides and their use | 拜耳股份公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109689656-A | 7-substituted 1-arylnaphthyridine-3-carboxamides and their use | 拜耳股份公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109689656-A | 7-substituted 1-arylnaphthyridine-3-carboxamides and their use | 拜耳股份公司 | 2019-04-26 | — | — | CN | disclosed |