Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | MAP2K3 | P46734 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.44 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992814 | 0.82 | TDP1 (0.56) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL634399 | 0.82 | ALDH1A1 (0.72) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3701892 | 0.82 | TDP1 (0.56) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL10562751 | 0.80 | ALDH1A1 (0.69) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28296154 | 0.78 | ALDH1A1 (0.79) | TDP1MAPTALDH1A1SMN1; SMN2IKBKB | |
| SCHEMBL4101721 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2IKBKBMAP2K3 | |
| SCHEMBL43146 | 0.78 | MAPT (0.54) | TDP1MAPTALDH1A1SMN1; SMN2IKBKB | |
| SCHEMBL3712426 | 0.77 | ALDH1A1 (0.53) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11206926 | 0.76 | TDP1 (0.75) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E | |
| Bicarbonate SCHEMBL10870596 | 0.76 | TDP1 (0.75) | TDP1MAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115397444-A | Compositions and methods for allograft transplantation | 美真达治疗公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-112154152-A | anti-CD 252 antibodies, conjugates, and methods of use | 美真达治疗公司 | 2020-12-29 | — | — | CN | disclosed |
| EP-2118076-B1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO SA (CH) | 2019-09-04 | — | — | EP | disclosed |
| US-8895559-B2 | Quinoxalines derivatives and pharmaceutical compositions and kits | MERCK PATENT GMBH (DE) | 2014-11-25 | — | — | US | disclosed |
| US-8614215-B2 | Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks) | MERCK SERONO SA (CH) | 2013-12-24 | — | — | US | disclosed |
| US-20130217670-A1 | QUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | MERCK SERONO SA (CH) | 2010-06-03 | — | — | US | disclosed |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| EP-2118076-A1 | QUINOXALINE COMPOUNDS AND USE THEREOF | Merck Serono S.A. (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
| WO-2008101979-A1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217670-A1 | QUINOXALINE DERIVATIVES | PIK3R5, NQO2, PIK3R1 | TDP1 458/4885MAPT 4120/4885ALDH1A1 2771/4885 |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | PFKP, PDXK, PF4 | TDP1 1561/4885MAPT 3821/4885ALDH1A1 577/4885 |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP4K2, MAP3K5 | TDP1 857/4885MAPT 1694/4885ALDH1A1 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.