SCHEMBL43146

SCHEMBL43146

NC(=O)c1nc2ccccc2nc1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.54
ALDH1A1 P00352 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MAP2K3 P46734 2/20 0.46
LCK P06239 1/20 0.46
MAP2K6 P52564 1/20 0.46
BTK Q06187 1/20 0.46
MAP3K19 Q56UN5 1/20 0.46
NEK10 Q6ZWH5 1/20 0.46
IKBKB O14920 3/20 0.42
ADORA2A P29274 1/20 0.41
PIM1 P11309 2/20 0.40
HSD17B10 Q99714 4/20 0.39
KDM4E B2RXH2 3/20 0.39
HPGD P15428 2/20 0.39
GAA P10253 2/20 0.39
PPARG P37231 1/20 0.39
NCOA2 Q15596 1/20 0.39
TSHR P16473 2/20 0.39
THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL42617 0.81 ALDH1A1 (0.75) MAPTALDH1A1SMN1; SMN2PIM1HSD17B10
SCHEMBL4101721 0.79 ALDH1A1 (0.56) MAPTALDH1A1SMN1; SMN2MAP2K3LCK
SCHEMBL28296154 0.79 ALDH1A1 (0.79) MAPTALDH1A1SMN1; SMN2MAP2K3LCK
SCHEMBL6991670 0.79 ALDH1A1 (0.54) MAPTALDH1A1SMN1; SMN2PIM1HSD17B10
SCHEMBL47270 0.79 MAPT (0.54) MAPTALDH1A1SMN1; SMN2PIM1HSD17B10
SCHEMBL3574871 0.78 TDP1 (0.54) MAPTALDH1A1SMN1; SMN2MAP2K3LCK
Bicarbonate SCHEMBL11185192 0.75 ALDH1A1 (0.58) MAPTALDH1A1SMN1; SMN2PIM1HSD17B10
SCHEMBL23308057 0.75 ALDH1A1 (0.48) MAPTALDH1A1SMN1; SMN2PIM1HSD17B10
SCHEMBL4099973 0.75 ALDH1A1 (0.48) MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E
SCHEMBL9114558 0.75 MAPT (0.48) MAPTALDH1A1SMN1; SMN2MAP2K3LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260056191-A1 POLYMERS AND CONJUGATES COMPRISING THE SAME VENTANA MEDICAL SYSTEMS, INC. (US) 2026-02-26 US claimed
US-20250271441-A1 APPLICATION OF CLICK CHEMISTRY FOR SIGNAL AMPLIFICATION IN IHC AND ISH ASSAYS VENTANA MED SYST INC (US) 2025-08-28 US claimed
US-20240123045-A1 NONAUTOLOGOUS MULTI-STRESSED CANCER CELLS AND USES THEREOF FOR VACCINATING AND TREATING CANCERS BRENUS PHARMA (FR) 2024-04-18 US claimed
EP-4297874-A1 NONAUTOLOGOUS MULTI-STRESSED CANCER CELLS AND USES THEREOF FOR VACCINATING AND TREATING CANCERS BRENUS PHARMA (FR) 2024-01-03 EP claimed
US-11780863-B2 Quinone methide analog signal amplification VENTANA MEDICAL SYSTEMS, INC. (US) 2023-10-10 US claimed
WO-2022180251-A1 NONAUTOLOGOUS MULTI-STRESSED CANCER CELLS AND USES THEREOF FOR VACCINATING AND TREATING CANCERS BRENUS PHARMA (FR) 2022-09-01 WO claimed
US-11079372-B2 Polymers and conjugates comprising the same VENTANA MEDICAL SYSTEMS, INC. (US) 2021-08-03 US claimed
US-10775281-B2 Polymer stabilization of chromogen solutions VENTANA MEDICAL SYSTEMS, INC. (US) 2020-09-15 US claimed
US-20200271662-A1 PROXIMITY ASSAYS USING CHEMICAL LIGATION AND HAPTEN TRANSFER VENTANA MED SYST INC (US) 2020-08-27 US claimed
US-20180120306-A1 HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE VENTANA MED SYST INC (US) 2018-05-03 US claimed
US-20120301886-A1 POLYTAG PROBES VENTANA MEDICAL SYSTEMS, INC. 2012-11-29 US claimed
US-20120237930-A1 METHOD OF ANALYZING CHROMOSOMAL TRANSLOCATIONS AND A SYSTEM THEREFORE VENTANA MEDICAL SYSTEMS, INC. 2012-09-20 US claimed
WO-2012123387-A1 A METHOD OF ANALYZING CHROMOSOMAL TRANSLOCATIONS AND A SYSTEM THEREFORE F. HOFFMANN-LA ROCHE AG (CH) 2012-09-20 WO claimed
EP-2444806-A2 Haptens, hapten conjugates, compositions thereof and method for their preparation and use Ventana Medical Systems, Inc. (US) 2012-04-25 EP claimed
US-20100297725-A1 Haptens, hapten conjugates, compositions thereof and method for their preparation and use VENTANA MEDICAL SYSTEMS, INC. 2010-11-25 US claimed
US-20100184087-A1 Haptens, hapten conjugates, compositions thereof and method for their preparation and use VENTANA MEDICAL SYSTEMS, INC. 2010-07-22 US claimed
EP-2078197-A2 HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE Ventana Medical Systems, Inc. (US) 2009-07-15 EP claimed
US-20080268462-A1 Derivatives containing oxazole, pyrazole, thiazole, nitroaryl compound, benzofurazan, triterpene, urea, thiourea, rotenoid, coumarin or cyclolignan such as 4-(2-hydroxyphenyl)-1H-benzo[b][1,4]diazepine-2(3H)-one; multiplexed diagnostic assay for multiple targets in sample; antibodies; kits VENTANA MEDICAL SYSTEMS, INC. 2008-10-30 US claimed
WO-2008063378-A9 HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE VENTANA MED SYST INC (US) 2008-07-31 WO claimed
WO-2008063378-A2 HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE VENTANA MEDICAL SYSTEMS, INC. (US) 2008-05-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080268462-A1 Derivatives containing oxazole, pyrazole, thiazole, nitroaryl compound, benzofurazan, triterpene, urea, thiourea, rotenoid, coumarin or cyclolignan such as 4-(2-hydroxyphenyl)-1H-benzo[b][1,4]diazepine-2(3H)-one; multiplexed diagnostic assay for multiple targets in sample; antibodies; kits HRH4, CRBN, NCDN MAPT 3454/4885ALDH1A1 2096/4885SMN1; SMN2 4773/4885
US-20180120306-A1 HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE CRBN, AHR, RORB MAPT 2927/4885ALDH1A1 2734/4885SMN1; SMN2 4647/4885
US-20260056191-A1 POLYMERS AND CONJUGATES COMPRISING THE SAME POLD1, POLL, INCENP MAPT 2231/4885ALDH1A1 640/4885SMN1; SMN2 1392/4885
US-20250271441-A1 APPLICATION OF CLICK CHEMISTRY FOR SIGNAL AMPLIFICATION IN IHC AND ISH ASSAYS MKI67, TIE1, ALK MAPT 4162/4885ALDH1A1 37/4885SMN1; SMN2 4575/4885
US-11780863-B2 Quinone methide analog signal amplification NQO2, SQOR, MRM1 MAPT 4787/4885ALDH1A1 208/4885SMN1; SMN2 3661/4885
US-20100297725-A1 Haptens, hapten conjugates, compositions thereof and method for their preparation and use CRBN, GABBR1, SHBG MAPT 2915/4885ALDH1A1 3347/4885SMN1; SMN2 4733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.