Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31573835 | 0.90 | CHRM2 (0.48) | THRBSCN8AKDM4ECHRM2HPGD | |
| SCHEMBL11876896 | 0.88 | CHRM2 (0.49) | THRBSCN8AKDM4ECHRM2HPGD | |
| SCHEMBL28200011 | 0.81 | THRB (0.49) | THRBTSHRHPGDCYP3A4CYP2D6 | |
| SCHEMBL4596466 | 0.78 | ESR1 (0.43) | THRBCD38KDM4ETSHRHPGD | |
| Bromide SCHEMBL28522221 | 0.77 | HPGD (0.46) | THRBP2RX7HPGDALDH1A1TP53 | |
| SCHEMBL28536283 | 0.75 | HPGD (0.47) | THRBP2RX7HPGDALDH1A1TP53 | |
| Bromide SCHEMBL29161130 | 0.75 | THRB (0.53) | THRBKDM4E | |
| SCHEMBL3284650 | 0.74 | THRB (0.54) | THRBKDM4E | |
| Hydrochloric Acid SCHEMBL28458294 | 0.72 | THRB (0.53) | THRBKDM4E | |
| SCHEMBL148311 | 0.72 | THRB (0.55) | THRBKDM4ETSHRHPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104685976-B | The manufacturing method of conductive pattern | 东丽株式会社 | 2019-05-31 | — | — | CN | disclosed |