SCHEMBL148311

SCHEMBL148311

C=CC(=O)OCCc1ccccc1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.55
ALOX5 P09917 3/20 0.54
TSHR P16473 5/20 0.47
ALDH1A1 P00352 3/20 0.47
TP53 P04637 2/20 0.47
HIF1A Q16665 2/20 0.47
HSD17B10 Q99714 1/20 0.47
THRA P10827 1/20 0.43
HPGD P15428 1/20 0.43
CYP3A4 P08684 1/20 0.43
CHRM5 P08912 1/20 0.42
CHRM1 P11229 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
HCAR2 Q8TDS4 1/20 0.41
KDM4E B2RXH2 1/20 0.40
GPR84 Q9NQS5 1/20 0.39
AKR1B10 O60218 2/20 0.39
AKR1B1 P15121 2/20 0.39
GAA P10253 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29745732 1.00 THRB (0.55) THRBALOX5TSHRALDH1A1TP53
SCHEMBL27715806 0.89 TSHR (0.51) THRBALOX5TSHRALDH1A1TP53
SCHEMBL28200011 0.88 THRB (0.49) THRBALOX5TSHRALDH1A1TP53
SCHEMBL27748616 0.84 THRB (0.55) THRBALOX5TSHRALDH1A1TP53
SCHEMBL1591973 0.83 MAOB (0.46) THRBALOX5TSHRALDH1A1THRA
SCHEMBL16672648 0.83 ALOX5 (0.60) ALOX5CYP3A4CHRM5CHRM1TAAR1
SCHEMBL16672655 0.83 ALOX5 (0.60) ALOX5CYP3A4CHRM5CHRM1TAAR1
SCHEMBL961984 0.82 THRB (0.57) THRBALOX5TSHRALDH1A1TP53
SCHEMBL30775445 0.82 THRB (0.57) THRBALOX5TSHRALDH1A1TP53
SCHEMBL28338758 0.82 THRB (0.57) THRBALOX5TSHRALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 353 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260003210-A1 DIFFRACTIVE CONTACT LENSES ALCON INC (CH) 2026-01-01 US claimed
US-12379611-B2 Diffractive contact lenses ALCON INC. (CH) 2025-08-05 US claimed
EP-4121802-B1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES ALCON INC (CH) 2024-07-17 EP claimed
US-20240142665-A1 OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2024-05-02 US claimed
EP-4356169-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2024-04-24 EP claimed
US-20240117092-A1 OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2024-04-11 US claimed
EP-4284787-A1 OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-12-06 EP claimed
EP-4263513-A1 OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-10-25 EP claimed
US-11618823-B2 High refractive index siloxane insert materials for embedded contact lenses ALCON INC. (CH) 2023-04-04 US claimed
EP-4121802-A1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES Alcon Inc. (CH) 2023-01-25 EP claimed
EP-1079870-A1 BICOMPOSITE INTRAOCULAR LENS AND METHOD FOR ITS PREPARATION Alcon Laboratories, Inc. (US) 2001-03-07 EP claimed
US-6187042-B1 COMPRISING A SUBSTRATE AND A COATING FOR MAKING THE LENS MORE BIOCOMPATIBLE AND REDUCING THE RISK OF POSTERIOR CAPSULE OPACIFICATION, THE COATING IS BASED ON A POLYMER OF TWO HYDROPHOBIC ACRYLIC ESTERS CONTAINING A PHENYL GROUP ALCON LABORATORIES, INC. 2001-02-13 US claimed
EP-1071482-A1 INTRAOCULAR LENS COATING COMPOSITIONS Alcon Laboratories, Inc. (US) 2001-01-31 EP claimed
EP-1002244-A1 METHOD OF PREPARING FOLDABLE HIGH REFRACTIVE INDEX ACRYLIC OPHTHALMIC DEVICE MATERIALS ALCON LABORATORIES, INC. (US) 2000-05-24 EP claimed
WO-1999053348-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS PREPARED USING A POST-POLYMERIZATION CROSS-LINKING METHOD ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed
WO-1999053347-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed
WO-1999052570-A1 INTRAOCULAR LENS COATING COMPOSITIONS ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed
WO-1999052571-A1 BICOMPOSITE INTRAOCULAR LENS AND METHOD FOR ITS PREPARATION ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed
US-5891931-A CONTAINING A CURABLE ACRYLATED RESIN POLYMER ALCON LABORATORIES, INC. (US) 1999-04-06 US claimed
WO-1999008136-A1 METHOD OF PREPARING FOLDABLE HIGH REFRACTIVE INDEX ACRYLIC OPHTHALMIC DEVICE MATERIALS ALCON LABORATORIES, INC. (US) 1999-02-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260003210-A1 DIFFRACTIVE CONTACT LENSES LBR, CRYZ, CRYAA THRB 2506/4885ALOX5 2585/4885TSHR 1437/4885
US-20240117092-A1 OPTICALLY ACTIVE DEVICES PDE6C, UACA, PDE6A THRB 4655/4885ALOX5 36/4885TSHR 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.