Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28536283 | 0.99 | HPGD (0.47) | HPGDPOLBMEN1KMT2ANPC1 | |
| SCHEMBL19291843 | 0.79 | MAPK1 (0.52) | KMT2ANPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL5848878 | 0.79 | MAPK1 (0.52) | KMT2ANPC1RAB9ASMN1; SMN2MAPK1 | |
| Bromide SCHEMBL28296902 | 0.77 | THRB (0.40) | HPGDP2RX7THRBALDH1A1TP53 | |
| SCHEMBL29315485 | 0.75 | CHRNB2 (0.52) | MEN1KMT2ASMN1; SMN2MAPK1THRB | |
| SCHEMBL28483635 | 0.75 | ALDH1A1 (0.63) | HPGDPOLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL2228385 | 0.74 | MEN1 (0.54) | HPGDPOLBMEN1KMT2ANPC1 | |
| SCHEMBL28504974 | 0.74 | SMN1; SMN2 (0.61) | HPGDPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3250210 | 0.73 | ITGB3 (0.57) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL13328798 | 0.73 | THRB (0.43) | HPGDMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112470318-A | Electrolyte composition, electrolyte membrane, and method for producing electrolyte membrane | 株式会社日本触媒 | 2021-03-09 | — | — | CN | disclosed |