Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | TERT | O14746 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARD | Q03181 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | TOP1 | P11387 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL701382 | 0.98 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL6562024 | 0.98 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL29092873 | 0.98 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL8572179 | 0.98 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL28327597 | 0.98 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL16027137 | 0.95 | TSHR (0.71) | TSHRALDH1A1MAPTABCC4EP300 | |
| Maleic Acid SCHEMBL6666189 | 0.93 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4EP300 | |
| Maleic Acid SCHEMBL398163 | 0.93 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4EP300 | |
| Maleic Acid SCHEMBL28894453 | 0.93 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4EP300 | |
| Fumaric Acid SCHEMBL3116844 | 0.93 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108002430-B | A kind of Cs of small size high stability4PbBr6The nanocrystalline preparation method of perovskite | 吉林大学 | 2019-05-03 | — | — | CN | disclosed |