Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 2/20 | 0.48 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6666189 | 1.00 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4HCAR2 | |
| Maleic Acid SCHEMBL28894368 | 1.00 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4HCAR2 | |
| Maleic Acid SCHEMBL28894453 | 1.00 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4HCAR2 | |
| Fumaric Acid SCHEMBL3116844 | 1.00 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4HCAR2 | |
| Maleic Acid SCHEMBL3116841 | 1.00 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4HCAR2 | |
| Maleic Acid SCHEMBL8915327 | 0.94 | TSHR (0.61) | TSHRMAPTPTPN1TERTBLM | |
| Bicarbonate SCHEMBL28297401 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4PTPN1 | |
| Acrylic Acid SCHEMBL15284280 | 0.91 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4PTPN1 | |
| Acrylic Acid SCHEMBL9955535 | 0.91 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4PTPN1 | |
| Acrylic Acid SCHEMBL15284291 | 0.91 | TSHR (0.70) | TSHRALDH1A1MAPTABCC4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101546-B2 | Thermal recording material | KURARAY CO., LTD. (JP) | 2012-01-24 | — | — | US | disclosed |
| EP-1920941-B1 | THERMAL RECORDING MATERIAL | KURARAY CO (JP) | 2010-12-22 | — | — | EP | disclosed |
| US-20090264288-A1 | THERMAL RECORDING MATERIAL | KURARAY CO., LTD. (JP) | 2009-10-22 | — | — | US | disclosed |
| EP-1920941-A1 | THERMAL RECORDING MATERIAL | Kuraray Co., Ltd. (JP) | 2008-05-14 | — | — | EP | disclosed |