Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 3/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | TOP1 | P11387 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28327597 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL701382 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL29092873 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL8572179 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL28297401 | 0.98 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL16027137 | 0.98 | TSHR (0.71) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL20420819 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL2553321 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL6701013 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL30632143 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397479-A1 | CLEANING SYSTEM INCLUDING A LIQUID CLEANING COMPOSITION DISPOSED IN A WATER SOLUBLE CONTAINER | Colgate-Palmolive Company (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002102958-A1 | CLEANING SYSTEM INCLUDING A LIQUID CLEANING COMPOSITION DISPOSED IN A WATER SOLUBLE CONTAINER | COLGATE-PALMOLIVE COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |
| US-6486109-B1 | Cleaning system including a liquid cleaning composition disposed in a water soluble container | COLGATE-PALMOLIVE COMPANY | 2002-11-26 | — | — | US | disclosed |
| US-6444632-B1 | POLYVINYL ALCOHOL CONTAINER OF LIQUID CLEANING COMPOSITION COMPRISING NONIONIC SURFACTANT; FATTY ACID, WATER INSOLUBLE ORGANIC ESTER AND/OR SILICONE FLUID; PERFUME, ESSENTIAL OIL OR WATER INSOLUBLE ORGANIC COMPOUND; SHORT CHAIN AMPHIPHILE | COLGATE-PALMOLIVE COMPANY | 2002-09-03 | — | — | US | disclosed |
| US-5733860-A | ANIONIC SURFACTANTS, ALKYLENE CARBONATE, ELECTROLYTES AND WATER | COLGATE-PALMOLIVE COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| WO-1998000418-A1 | ALKYLENE CARBONATES AND THEIR PREPARATION | COLGATE-PALMOLIVE COMPANY (US) | 1998-01-08 | — | — | WO | disclosed |