Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 3/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | TOP1 | P11387 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6562024 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL28327597 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL29092873 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL8572179 | 1.00 | TSHR (0.76) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL28297401 | 0.98 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Bicarbonate SCHEMBL16027137 | 0.98 | TSHR (0.71) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL20420819 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL2553321 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL6701013 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 | |
| Acetic Acid SCHEMBL30632143 | 0.93 | TSHR (0.73) | TSHRALDH1A1MAPTABCC4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 138 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3772943-B1 | FORMULATION OF INSECTICIDAL MIXTURES WITH PROPYLENE CARBONATE | BAYER AG (DE) | 2026-05-06 | — | — | EP | claimed |
| US-11919844-B2 | Method for fabricating polyols | ORIENTAL UNION CHEMICAL CORP. (TW) | 2024-03-05 | — | — | US | claimed |
| EP-4275492-A1 | FORMULATION OF INSECTICIDES COMPRISING PROPYLENE CARBONATE | Bayer Aktiengesellschaft (DE) | 2023-11-15 | — | — | EP | claimed |
| EP-3467035-B1 | POLYKETONE RESIN COMPOSITION AND POLYKETONE RESIN MOLDED ARTICLE | LG CHEMICAL LTD (KR) | 2023-04-05 | — | — | EP | claimed |
| US-11613507-B2 | Method for fabricating a high-activity double-metal-cyanide catalyst | ORIENTAL UNION CHEMICAL CORP. (TW) | 2023-03-28 | — | — | US | claimed |
| US-11602740-B2 | High-activity double-metal-cyanide catalyst | ORIENTAL UNION CHEMICAL CORP. (TW) | 2023-03-14 | — | — | US | claimed |
| US-20220330546-A1 | FORMULATION OF INSECTICIDES COMPRISING PROPYLENE CARBONATE | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-20 | — | — | US | claimed |
| EP-4040960-A1 | FORMULATION OF INSECTICIDES COMPRISING PROPYLENE CARBONATE | Bayer Aktiengesellschaft (DE) | 2022-08-17 | — | — | EP | claimed |
| CN-114650731-A | Pesticide formulations containing propylene carbonate | 拜耳公司 | 2022-06-21 | — | — | CN | claimed |
| CN-110088197-B | Polyalkylene carbonate-based resin film | LG化学株式会社 | 2021-12-28 | — | — | CN | claimed |
| US-10844220-B2 | Polyketone resin composition and polyketone resin molded article | LG CHEM, LTD. (KR) | 2020-11-24 | — | — | US | claimed |
| CN-111970927-A | Insecticidal mixture formulation comprising propylene carbonate | 拜耳公司 | 2020-11-20 | — | — | CN | claimed |
| WO-2019197635-A1 | FORMULATION OF INSECTICIDAL MIXTURES COMPRISING PROPYLENE CARBONATE | BAYER AKTIENGESELLSCHAFT (DE) | 2019-10-17 | — | — | WO | claimed |
| US-20190185399-A1 | HIGH-ACTIVITY DOUBLE-METAL-CYANIDE CATALYST, METHOD FOR FABRICATING THE SAME, AND APPLICATIONS OF THE SAME | ORIENTAL UNION CHEMICAL CORP. (TW) | 2019-06-20 | — | — | US | claimed |
| EP-3467035-A1 | POLYKETONE RESIN COMPOSITION AND POLYKETONE RESIN MOLDING | LG Chem, Ltd. (KR) | 2019-04-10 | — | — | EP | claimed |
| CN-109301324-A | A kind of lithium ion battery with high energy density electrolyte | 天津市捷威动力工业有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-109244534-A | A kind of montmorillonite-base composite solid electrolyte and solid state lithium battery | 北京科技大学 | 2019-01-18 | — | — | CN | claimed |
| US-20150099191-A1 | Co-solvents with High Coulombic Efficiency in Propylene Carbonate Based Electrolytes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-04-09 | — | — | US | claimed |
| EP-0848444-B1 | Process for manufacturing polymer electrolytes | VARTA MICROBATTERY GMBH (DE) | 2004-02-11 | — | — | EP | claimed |
| US-6077627-A | LITHIUM BATTERIES | VARTA BATTERIE AKTIENGESELLSCHAFT (DE) | 2000-06-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185399-A1 | HIGH-ACTIVITY DOUBLE-METAL-CYANIDE CATALYST, METHOD FOR FABRICATING THE SAME, AND APPLICATIONS OF THE SAME | HACL2, COASY, CYCS | TSHR 4579/4885ALDH1A1 1363/4885MAPT 4606/4885 |
| US-20220330546-A1 | FORMULATION OF INSECTICIDES COMPRISING PROPYLENE CARBONATE | PTMS, PDE8B, CYP51A1 | TSHR 2541/4885ALDH1A1 3721/4885MAPT 2632/4885 |
| US-11919844-B2 | Method for fabricating polyols | HACL2, LIPC, ACSL1 | TSHR 4452/4885ALDH1A1 1614/4885MAPT 4385/4885 |
| US-11602740-B2 | High-activity double-metal-cyanide catalyst | CYCS, HACL2, CYC1 | TSHR 4427/4885ALDH1A1 1793/4885MAPT 4595/4885 |
| US-11613507-B2 | Method for fabricating a high-activity double-metal-cyanide catalyst | LIPC, HACL2, CYCS | TSHR 4334/4885ALDH1A1 1880/4885MAPT 4552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.