Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL1792710 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL28918498 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL2487171 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL1134753 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL5161896 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL468813 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL6662558 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL15463836 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL468638 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL11313361 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109893460-A | A kind of composition of anti-sensitivity of tooth containing lithium salt and its application | 吕天宽 | 2019-06-18 | — | — | CN | disclosed |
| CN-109846731-A | A kind of composition of anti-sensitivity of tooth containing lithium salt | 吕天宽 | 2019-06-07 | — | — | CN | disclosed |