Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL6408549 | 0.89 | TSHR (0.90) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL194401 | 0.89 | TSHR (0.90) | TSHRALDH1A1LMNANFKB1PMP22 | |
| Maleic Acid SCHEMBL27875761 | 0.87 | TSHR (0.59) | TSHRALDH1A1LMNAHCAR2MAPT | |
| Sebacic Acid SCHEMBL10956921 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 | |
| Adipic Acid SCHEMBL3799583 | 0.87 | TSHR (0.95) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL3502474 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL905415 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL3504014 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 | |
| Adipic Acid SCHEMBL10792220 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL3503428 | 0.87 | TSHR (0.86) | TSHRALDH1A1LMNANFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109863237-A | Water-solubility membrane with low-friction coefficient | 蒙诺苏尔有限公司 | 2019-06-07 | — | — | CN | disclosed |